Raman Spectroscopy-Based Sensing of Glycated Hemoglobin: Critical Analysis and Future Outlook

Glycated hemoglobin is a clinically established important biomarker that provides retrospective value of blood glucose concentration over the preceding 2-3 months. Owing to the biochemical specificity and multiplexing capability, Raman spectroscopy has emerged as a promising tool for detection and quantification of blood constituents in a label-free and non-destructive manner. Here, we critically review the Raman spectroscopy-based approach to detect and quantify this important biomarker. The potential of this spectroscopy-based approach and its possible clinical translation from the current optical bench will be also briefly discussed along with the future prospects.